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The ingredient can be incorporated into a wide variety of formulations and perfectly fits the global trend towards milder products. What it’s in: The Ordinary Granactive Retinoid 2% Emulsion. Note: Prepared by Ronald V. Lerum, PhD, on Dec. 13, 2014. This skin care active ingredient belongs to a class of chemical compounds termed retinoids, which are natural and synthetic derivatives of Vitamin A capable of binding to retinoid receptors. Note: When pregnant or breastfeeding, it is recommended to avoid any skincare products containing retinoids such as formulations with Granactive Retinoid or Retinol. Irritation profile was taken after application on a 24-hour occlusive patch test. The Granactive Retinoid 2% in Squalane is a light-weight solution and absorbs into the skin efficiently, allowing for multiple serums to be applied in your regimen. Retinoids are widely regarded as being among the most powerful (if not the most powerful) and effective anti-aging active compounds available. Has anyone actually seen positive results with the granactive? The textures aren't great, that's true, but you can easily mix them. Irritation profile with a. Granactive Retinoid vs b. retinol, Thermal stress stability testing of Granactive Retinoid vs. Retinol in dimethyl isosorbide, Table 1. Additionally, OTC retinols are often combined with other ingredients, such as moisturizing ingredients, to minimize dryness/irritation, add antioxidants, or brighten the skin. After a month, I’m already seeing a bigger difference in results than I had with the Granactive Retinoids or HPR Oils. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. Like all retinoids, the highly specific set of conjugated double bonds are susceptible to oxidation resulting in degradation. Granactive Retinoid helps renew skin plumpness, elasticity, and hydration to provide a radiant and fresh appearance. This retinoid seemed the most appealing to me from their range of retinoids. The effectiveness of Granactive Retinoid at filling lines and wrinkles can be seen in Image 1. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. ‘Granactive Retinoid’ is a next-generation retinoid active technology, which can not only achieve better anti-ageing results than traditional retinol but do so without the irritation commonly associated with it (it often causes redness and flaking). These derivatives are metabolized to the active form by skin cells. Although the benefits of retinoids have been known for decades, skin irritation, photochemical instability, and toxicity concerns have hindered their use. Our science is complex, but the results are simple. The binding of retinoid receptors can enhance gene expression, which effectively turns key cellular functions on and off. Questions? The 10% refers to the complex, which is granactive retinoid + the solvent dimethyl isosorbide in a 1:9 solution. Granactive Retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid. Granactive Retinoid offers formulators the ability to harness the powerful anti-aging properties of retinoid without irritation and stability issues traditionally associated with older generations of vitamin A analogues. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE All rights reserved. Granactive Retinoid is a next-generation anti-aging product, delivering the performance of retinol and retinoid derivatives with significantly lower irritation potential, thus supporting clear, visibly more youthful looking skin with better consumer acceptance. Granactive Retinoid is compliant in most global regions, including China. It is a delivery system for the active ingredient hydroxypinacolone retinoate (HPR), which is a retinoic acid ester. Stimulating these age-defying processes in the skin is critical for fighting and reversing signs of aging. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin complexion are switched on. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Retinoic acid is a topically applied ingredient recognized for its anti-aging benefits, however it can be irritating to skin and is sold as a prescription medication. Retinoids don’t take as much time to reach that final product, so they’re more intense than retinol. But not only is it less irritating than tretinoin, it is also less irritating than even 0.5 percent retinol. Retinoids are known to have positive effect on aged skin.1 The novel retinoid combats the appearance of fine lines and wrinkles for a younger appearance while increasing skin elasticity for firmer, smoother skin texture. This is an ideal progression from the above 2 percent option if you want to take it up a notch. The Ordinary’s extended portfolio of retinoids includes the following formulations: Granactive Retinoid 2% Emulsion (Moderate Strength, No Irritation) Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) Granactive Retinoid 5% in Squalane (High Strength, No to Low Irritation) Retinol 0.2% in Squalane (Low Strength, Moderate Irritation) Retinol 0.5% in Squalane (Moderate Strength, High … These processes help fill in lines and wrinkles to give a youthful appearance, while safeguarding skin from further wrinkle development. The next-generation anti-aging formula with 2% Granactive Retinoid is dermatologically tested to offer less irritation & multi-fold better effect than other retinol and retinoid derivatives Boosts cell turnover & stimulates collagen production to erase fine lines and wrinkles, revealing radiant glowy skin Since HPR binds directly to retinoid receptors, its activity is similar to pure retinoic acid. The mechanism of action of Granactive Retinoid is advanced compared to retinol derivatives. Granactive Retinoid is highly recommended for promoting clear skin when used in conjunction with monographed anti-acne treatments. Retinol (vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. Log out Both samples were prepared to a working stock concentration of 0.1% wt. Sample preparation: Granactive Retinoid is 10% wt. Reduction of lines and wrinkles after 14-day Granactive Retinoid application, Figure 2. The novel retinoid is unique in that it processes innate retinoic activity, binding directly with retinoid receptors without the need for metabolic breakdown to more biologically active forms. Granactive Retinoid 2% in Squalane (Moderate Strength, No Irritation) 2. So your skin prefers retinoids to acids, that's an important discovery! Search results for. When a product claims 2% Granactive Retinoid, it means 0.2% Hydroxypinacolone Retinoate (and 1.8% dimethyl isosorbide) on the ingredient list. Bakuchiol: International journal of cosmetic science 36 (3) DOI: 10.1111/ics.12117 Source: PubMed January 2014 This time varies: some people say 2 months, or 3 months, or 6 months. Granactive Retinoid, an active technology from Grant Industries, is a solubilized system of Hydroxypinacolone Retinoate, a highly-advanced form of retinoid which is, in fact, a non-prescription ester of all-trans direct retinoic acid that offers a multi-fold better effect against signs of aging than retinol, retinyl palmitate and nearly all other forms of non-prescription retinoid. As we age our skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. The same process improves overall skin clarity, and appearance is enhanced for a healthier complexion. As a result, conventional antioxidants such as vitamin E, BHT, BHA etc. The Ordinary Granactive Retinoid; Overall Rating: Texture/Feel: Thin, watery texture: Application: Super easy to apply with the dropper: Drying Time: Dries in about 10 seconds: Smell: Virtually no smell: Short Term Results: Hydrated and soft skin: Long Term Results: Helps reduce the appearance of fine lines: Ingredients: Caprylic is used to help the skin retain moisture. Allured Business Media utilizes Omeda to collect information on its behalf. Congrats on your results, it sounds amazing. Contact her at gmazur@timesshamrock.com , … It is apparent from the HPLC data that under similar conditions that the retinol is highly unstable. Granactive Retinoid 5% in Squalane is a water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of ageing than retinol without any of the irritation and drawbacks common with retinol. The Ordinary Granactive Retinoid 2% In Squalane, 30 Milliliters 4.4 out of 5 stars 482 CDN$ 79.55 CDN$ 79 . and were stored in low actinic glass bottles under a blanket of nitrogen gas. This water-free solution contains a 5% concentration of an advanced retinoid active complex called Granactive Retinoid that has been shown to offer better results against multiple signs of aging than retinol without any of the irritation and drawbacks common with retinol. The Ordinary Granactive Retinoid 2% Emulsion Garden of Wisdom Granactive Retinoid 5% Serum Be Minimalist Granactive Retinoid 2% (Emulsion) BFFECT Granactive Retinoid Emulsion 2% + Gaba The Ordinary Granactive Retinoid 2% In Squalane The Ordinary Granactive Retinoid 5% In Squalane Pacifica Clean Shot Granactive Retinoid 5% In Seawater This Works My … The two primary reasons the use of retinoids is not universal are issues surrounding irritation potential and stability. Our patients’ results speak for themselves. To interact with retinoid receptors, retinol must first be metabolized to more active forms, such as retinaldehyde and retinoic acid using several enzymatic steps. Granactive Retinoid (now referred to as ‘the novel retinoid’) helps renew skin plumpness, elasticity and hydration to provide a radiant and fresh appearance. CHALLENGES WITH OLDER GENERATION VITAMIN A CHEMISTRIES. The novel retinoid is intended to support anti-aging and anti-acne beauty treatments by providing low irritating, effective active delivery in daily maintenance applications. To minimize the effects due to light and air oxidation, the products were stored in low actinic glassware and under nitrogen atmosphere. An aliquot was removed at specified times and tested by high performance liquid chromatography (HPLC). To “unsubscribe,” click the link at the bottom of any e-mail we send. a) A 2% concentration of Granactive Retinoid which is a complex of solubilized Hydroxypinacolone Retinoate (HPR). It is listed as an approved existing ingredient on China’s 2014 IECIC list. So when you see a percentage of granactive retinoid being quoted, be aware that you need to divide by 10 to get the actual concentration of HPR. It has been shown to offer results against multiple signs of aging without the common drawbacks often associated with retinol. As humans age, skin becomes thinner and less elastic, leading to skin with a loose, sagging, and wrinkled appearance. … Welcome Stimulating these age defying processes in the skin is critical for fighting and reversing signs of aging. The novel retinoid should be added to the oil phase of all emulsion types, with a clinical use level of 1-2%. Like the above, the Granactive Retinoid 5% in Squalane ($14) is a higher concentration of the lightweight Granactive retinoid. 625SI.1 - January 15, 2014 3. The mechanism of action of the novel retinoid is advanced compared to retinol derivatives. The novel retinoid is dermatologically tested to offer less irritation potential than retinol, providing a gentle, safe and effective anti-aging retinoid (see Figure 2 and Table 1). When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit the skin complexion are switched on. The manufacturer produces it as 10% active and 90% solvent called dimethyl isosorbide. The Ordinary Granactive Retinoid 5% in Squalane, 1 oz (or 30 mil as the rest of the world says) for $13.90. Retinol esters are often used to lower the irritation potential and increase stability, but a tradeoff is decreased retinoid activity and benefits. GRANACTIVE RETINOID ADVANCES OPPORTUNITIES IN VITAMIN A SKIN CARE. In recent years, milder synthetic and natural derivatives have become popular alternatives to retinoic acid. hydroxypinacolone retinoate in dimethyl isosorbide (DMI). Gia Mazur is a staff writer for the Lifestyles Department of The Times-Tribune. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. The AHA Complex in Evening Detox is a trio of resurfacing Alpha Hydroxy Acids to deeply clean pores, help to banish breakouts and boost radiance. 1-201-791-6700. Due to its superior irritation and stability profile, Granactive Retinoid allows new and exciting opportunities with vitamin A, one of the most trusted efficacious anti-aging active ingredients. I'm thinking of switching to their non granactive retinol line. Retinol (>95%, Sigma‐Aldrich) was dissolved in DMI. This cosmetic ingredient promotes cell turnover and renewal, which translates to improved skin clarity and the appearance of a healthier complexion. The Power of Retinol Without the Irratation. These derivatives are metabolized to the active form by skin cells. Retinol (Vitamin A) is the most popular topical retinoid used to date, but its skin irritancy and instability to sunlight has limited its scope and appeal. Medica Labs uses scientifically proven ingredients to formulate advanced skin care products. There is a bit of skin pilling everyday but it’s minor, manageable, non-invasive and satisfying quite frankly. Granactive Retinoid shows up to 10x more stability than retinol in DMI especially when comparing the 50% residual content. The novel retinoid is available as a concentrated and easily formulated anhydrous matrix containing 10% of the retinoid active in a premium delivery solvent. I chose it because it is listed as high strength, but with no to low irritation. Instead in recent years, milder synthetic and natural derivatives have become popular alternatives to Retinoic acid. The samples were placed in a heated water bath at 50°C and shaken. Granactive Retinoid (INCI Name: Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate), is a cosmetic grade ester of all-trans retinoic acid. You may want to try the Granactive Retinoid in Squalan or Retinol in Squalan when you place your next TO order. This will deliver serious results with little to no irritation. Miscellaneous. The effectiveness of the novel retinoid at filling lines and wrinkles can be seen in Figure 1. Levin explains that while retinoids and retinol do exactly the same thing, it typically takes longer to see results from retinols compared to retinoids. Subscribe, Visit the website Test samples were 0.5% retinoid in Granactive DMI (INCI: Dimethyl Isosorbide). Moreover, the novel retinoid stimulates skin cell proliferation; restoring thickness to skin that has become thinner over time. Addressing these issues without adversely affecting efficacy provides a breakthrough in opportunities with vitamin A in cosmetic formulations. The Ordinary Retinol 0.2% in Squalane - 30ml, Reduce The Appearances of fine Lines, of Photo Damage and of General Skin ageing 4.4 out of 5 stars 636 £8.98£8.98 (£29.93/100 ml) £9.13£9.13 Get it … The novel retinoid delivers high performance compared to retinol derivatives, but with a significantly lower irritation potential. 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